Cart
sales@molnova.com
Rislenemdaz hydrochloride
CAS No. 808733-06-4
Rislenemdaz hydrochloride( MK 0657 | CERC 301 )
Catalog No. M16024 CAS No. 808733-06-4
Rislenemdaz (MK 0657;CERC 301) is a potent, orally bioavailable, brain‐penetrant, NR2B-selective NMDA receptor (GluN2B) antagonist with Ki and IC 50 of 8.1 nM and 3.6 nM respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameRislenemdaz hydrochloride
-
NoteResearch use only, not for human use.
-
Brief DescriptionRislenemdaz (MK 0657;CERC 301) is a potent, orally bioavailable, brain‐penetrant, NR2B-selective NMDA receptor (GluN2B) antagonist with Ki and IC 50 of 8.1 nM and 3.6 nM respectively.
-
DescriptionRislenemdaz (MK 0657;CERC 301) is a potent, orally bioavailable, brain‐penetrant, NR2B-selective NMDA receptor (GluN2B) antagonist with Ki and IC 50 of 8.1 nM and 3.6 nM respectively, with no off-target activity; inhibits calcium influx into agonist‐stimulated NMDA‐GluN1a/GluN2B L(tk‐) cells with IC50 of 3.6 nM, with no effect on GluN2A up to 30 uM; significantly decreases immobility frequency and increases swimming behavior in acute depression models.Depression Phase 2 Clinical.
-
In Vitro——
-
In Vivo——
-
SynonymsMK 0657 | CERC 301
-
PathwayMembrane Transporter/Ion Channel
-
TargetiGluR
-
RecptoriGluR
-
Research AreaNeurological Disease
-
IndicationDepression
Chemical Information
-
CAS Number808733-06-4
-
Formula Weight394.875
-
Molecular FormulaC19H24ClFN4O2
-
Purity>98% (HPLC)
-
Solubility——
-
SMILES——
-
Chemical Name4-methylbenzyl (3S,4R)-3-fluoro-4-((pyrimidin-2-ylamino)methyl)piperidine-1-carboxylate hydrochloride
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Addy C, et al. J Clin Pharmacol. 2009 Jul;49(7):856-64.
2. Ibrahim L, et al. J Clin Psychopharmacol. 2012 Aug;32(4):551-7.
3. Garner R, et al. Pharmacol Res Perspect. 2015 Dec 23;3(6):e00198.
molnova catalog
related products
-
LY450108
LY450108 is a potentiator of the AMPA receptor that can be used in Parkinson's disease studies.
-
Isomangiferin
Isomangiferin is the major tetracyclic oxindole alkaloid components of Uncaira species, inhibits NMDA receptor with IC50 of 43.2 uM.
-
Dynorphin A 1-10
Dynorphin A (1-10), an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor. Dynorphin A (1-10) also blocks NMDA-activated current with an IC50 of 42.0 μM.
